Publikationen - Dr. Toni Cathomen

Ausgewählte Publikationen:

Szczepek M, Brondani V, Büchel J, Serrano L, Segal DJ, and Cathomen T (2007) Structure-based redesign of the dimerization interface reduces the toxicity of zinc finger nucleases. Nat Biotechnol 25, 786-93.
Cornu TI, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung JK, and Cathomen T (2008) DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Mol Ther 16, 352-8.


Söllü C, Pars K, Cornu TI, Thibodeau-Beganny S, Maeder ML, Joung JK, Heilbronn R, and Cathomen T (2010) Autonomous zinc-finger nucleases for targeted chromosomal deletion. Nucleic Acids Res 38, 8269-76.


Mussolino C, Morbitzer R, Lütge F, Dannemann N Lahaye T, and Cathomen T (2011) A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res 39, 9283-93.


Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lütge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, and Cathomen T (2011) Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases. PLoS ONE 6, e28911.

Rahman SH, Bobis-Wozowicz S, Chatterjee D, Gellhaus K, Pars K, Heilbronn R, Jacobs R, and Cathomen T (2013) The non-toxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease mediated gene targeting. Hum Gene Ther 24, 67-77.


Bloom K, Ely A, Mussolino C, Cathomen T and Arbuthnot P (2013) Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered Transcription Activator-Like Effector Nucleases. Mol Ther 21, 1889-97.


Merkert S, Wunderlich S, Bednarski C, Beier J, Haase A, Dreyer A-K, Schwanke K, Meyer J, Göhring G, Cathomen T and Martin U (2014) Efficient designer nuclease-based homologous recombination enables direct PCR screening for footprintless targeted human pluripotent stem cells. Stem Cell Reports 2, 107-118.


Bobis-Wozowicz S, Galla M, Alzubi J, Kuehle J, Baum C, Schambach A and Cathomen T (2014) Non-integrating gamma-retroviral vectors as a versatile tool for transient zinc-finger nuclease delivery. Sci Rep


Mussolino C, Alzubi J, Fine EJ, Morbitzer R, Cradick TJ, Lahaye T, Bao G and Cathomen T (2014) TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity. Nucleic Acids Res